How can one overcome laziness, depression, and difficult psychological and health conditions that prevent the performance of prayer and making up for missed prayers?

Abandoning prayer is one of the gravest sins. One must preserve it and not neglect it, no matter how great the hardship. The reward for striving to maintain prayer is immense. As for missed prayers, there is a difference of opinion regarding the obligation to make them up. There is no harm in following the opinion of those who rule that making them up is not obligatory, if that helps one to maintain prayer in the future. It is advisable to consult the counseling section of the website and to visit a trusted doctor regarding psychological problems.